Traditional knowledge (TK) often helps researchers to locate, understand, and usefully apply genetic resources extracted from plants and animals. In some cases, TK provides the basis for cartographic insights and data on a wide range of otherwise inaccessible information. However, one of the sources of disquiet about TK is the perception that it is sometimes taken without permission, or when permission is given, TK may be used in a manner inconsistent with the expectations or wishes of the community. Even when researchers are working with Indigenous communities in good faith, there remains the risk of a misunderstanding or unintended misuse of the knowledge that can damage trust, build suspicion, and even cause economic, environmental, or other harm to the community.